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| Date | Opponents | Comp | Venue | Res | Att | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | | | | | |
| 8/18/51 | Bolton Wanderers | League | Home | 5-1 | | Crompton | McNulty | Killin | | Jones | Blanchflower | | Viollet | Ritchie 2 | Birch | Byrne 3 | | | | | |
| 8/22/51 | Leeds United | League | Away | 2-1 | | Crompton | McNulty | Killin | | Jones | Blanchflower | Clempson 1 | Viollet 1 | Ritchie | Birch | Byrne | | | | | |
| 8/25/51 | Newcastle United | League | Away | 0-3 | | Crompton | McNulty | Killin | | Jones | Blanchflower | | Viollet | Ritchie | Birch | Byrne | | | | | |
| 8/27/51 | Leeds United | League | Home | 0-1 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/1/51 | West Bromwich Albion | League | Home | 3-0 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/3/51 | Chesterfield | League | Away | 0-1 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/8/51 | Stoke City | League | Away | 0-1 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/10/51 | Chesterfield | League | Home | 4-0 | | Crompton | McNulty | Byrne | McIlvenny | Jones | McGlen | Scott 1 | Cassidy 1 | Ritchie 1 | Birch | Bond 1 | | | | | |
| 9/15/51 | Manchester City | League | Home | 2-2 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/22/51 | Everton | League | Home | 0-1 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 9/29/51 | Preston North End | League | Away | 2-0 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 10/6/51 | Liverpool | League | Away | 2-1 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 10/13/51 | Blackburn Rovers | League | Home | 3-0 | | Crompton | | | | Jones | | | | | Birch | | | | | | |
| 10/20/51 | Blackpool | League | Away | 2-4 | | Crompton | McNulty | Byrne | Whitefoot | Jones | Blanchflower | Scott | | Cassidy 1 | Birch 1 | | No 8 & 11 from: walton, clempson, Aston, Bond, Pegg | | | | |
| 10/24/51 | Bolton Wanderers | LSC | Away | | | | | | | | | | | | | | | | | | |
| 10/27/51 | Barnsley | League | Home | 0-0 | | Crompton | McNulty | Byrne | Whitefoot | Jones | McGlen | Scott | Clempson | Aston | Downie | Pegg | | | | | |
| 11/3/51 | Sheffield United | League | Away | 0-1 | | Crompton | McNulty | Byrne | Whitefoot | Jones | Blanchflower | Scott | | | Downie | | No 8, 9 & 11 from walton, clempson, aston, bond, pegg | | | | |
| 11/10/51 | Huddersfield Town | League | Home | 3-0 | | Crompton | McNulty | Byrne | Blanchflower | Jones | McGlen | Birkett 1 | Walton 1 | Cassidy | Birch | Bond 1 | | | | | |
| 11/17/51 | Wolverhampton Wdrs | League | Away | 1-0 | | | | | | Jones | | Birkett | | Cassidy | Birch | | scorer: Birch or Cassidy | | | | |
| 11/24/51 | Bury | League | Home | 2-0 | | | | | | Jones | | Birkett | | Cassidy | Birch | | scorers: Cassidy 2 or Birch & Cassidy | | | | |
| 12/1/51 | Aston Villa | League | Away | 0-2 | | | | | | Jones | | Birkett | | Cassidy | Birch | | | | | | |
| 12/8/51 | Derby County | League | Home | 0-0 | | | | | | Jones | | Birkett | | Cassidy | Birch | | | | | | |
| 12/15/51 | Bolton Wanderers | League | Away | 1-0 | | Wood | Foulkes | Redman | Gibson | Jones | Whitefoot | Birkett | Ritchie | Cassidy | Birch | Pegg | | | | | |
| 12/22/51 | Newcastle United | League | Home | 1-1 | | | | Redman | Gibson | | | Scott | Walton | | | | | | | | |
| 12/26/51 | Sheffield Wednesday | League | Home | 1-1 | | | | Redman | Gibson | | | Scott | Walton | | | | | | | | |
| 12/29/51 | West Bromwich Albion | League | Away | 0-3 | | Wood | Killin | Redman | Gibson | Cope | McGlen | Scott | Whitefoot | Aston | Walton | Pegg | *acc to t/s | | | | |
| 1/5/52 | Stoke City | League | Home | 3-0 | | | | Redman | Gibson | | | Scott | Walton | | | | | | | | |
| 1/12/52 | Sheffield Wednesday | League | Away | 0-2 | | Crompton | Foulkes | Redman | Whitefoot | Jones | McGlen | Scott | Walton | Aston | Birch | | | | | | |
| 1/19/52 | Manchester City | League | Away | 1-3 | | Crompton | Foulkes | Redman | Whitefoot | Jones | McGlen | Scott | Walton | Cassidy 1 | | | | | | | |
| 1/26/52 | Everton | League | Away | 1-1 | | Crompton | Foulkes | Redman | | Jones | | Birkett | | Cassidy | Downie | | | | | | |
| 2/2/52 | Burnley | League | Home | 0-1 | | Crompton | Foulkes | Redman | McIlvenny | Jones | Whitefoot | Birkett | Lewis | Cassidy | Birch | Pegg | | | | | |
| 2/9/52 | Preston North End | League | Home | 4-0 | | Crompton | Foulkes | Redman | | Jones | | Birkett | | Cassidy | Downie | | | | | | |
| 2/16/52 | Liverpool | League | Home | 6-1 | | Wood | Foulkes | Redman | Whitefoot | Jones | Bent | Scott | Doherty 1 | Cassidy 1 | Downie 2 | Bond 2 | | | | | |
| 3/1/52 | Blackburn Rovers | League | Away | 2-2 | | Wood | Foulkes | Redman | Whitefoot | Cope | Bent | Scott | Gibson 1 | Cassidy 1 | Downie | Bond | | | | | |
| 3/8/52 | Blackpool | League | Home | 3-0 | | Wood | Foulkes | Redman | Whitefoot | Cope | Bent | Scott | Gibson 1 | Cassidy 2 | Downie | Bond | | | | | |
| 3/15/52 | Barnsley | League | Away | 1-2 | | Wood | Foulkes | Redman | Whitefoot | Jones | | Scott | | Cassidy | Downie | Bond | Other apps from: Doherty | | Scorer: Cassidy or Downie | | |
| 3/22/52 | Sheffield United | League | Home | 1-1 | | Wood | Foulkes | Redman | Whitefoot | Jones | | Scott | | Cassidy | Downie | Bond | Bent, McGlen, Gibson | | Scorer: Cassidy or Downie | | |
| 3/29/52 | Huddersfield Town | League | Away | 1-2 | | Wood | | Redman | | Cope | | | | | Downie 1 | | | | | | |
| 4/5/52 | Wolverhampton Wdrs | League | Home | 1-3 | | | Foulkes | Redman | Gibson | | McGlen | Scott | | | Doherty | Pegg 1 | | | | | |
| 4/12/52 | Bury | League | Away | 0-1 | | | Foulkes | Redman | Gibson | | McGlen | Scott | | | Doherty | | | | | | |
| 4/14/52 | Burnley | League | Away | | | Wood | Foulkes | Redman | Gibson | Jones | McGlen | Scott | Clempson | Lewis | Doherty | Pegg | *acc to t/s | | | | |
| 4/19/52 | Aston Villa | League | Home | 3-1 | | Wood | Foulkes | Redman | Gibson | Jones | McGlen | Birkett 1 | Clempson 1 | Lewis 1 | McShane | Pegg | | | | | |
| 4/26/52 | Derby County | League | Away | 0-1 | | | | | | | | | | | | | | | | | |
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